Dr. Erica Manesso

My research interests are in the field of systems biology. I am involved in the development and implementation of mathematical and statistical models to investigate cell kinetics and molecular mechanisms characterizing biological systems in close collaboration with experimentalists.

• November 14^th, 2014: ”A Bayesian Design of Experiments for Ensemble Modeling of Gene Regulatory Networks”.
  Seventh Annual RECOMB/ISCB Conference on Regulatory and Systems Genomics, with DREAM Challenges and Cytoscape Workshops. San Diego, California, U.S.A., November 10-14, 2014.
• March 28^th, 2014: ”A systems biology approach to elucidate the kinetic and molecular mechanisms governing the T-cell lineage choice”. INRIA-antenne Lyon-La Doua, Lyon, France.
• May 2^nd, 2013: “From stem cells to T-lymphocyte lineage cells: a systems biology approach to elucidate the kinetic and molecular mechanisms controlling the transformation”. Department of Biology, École Normale Supérieure, Paris, France.
• March 27^th, 2013: “From stem cells to T-lymphocyte lineage cells: a systems biology approach to elucidate the kinetic and molecular mechanisms controlling the transformation”. Department of Information Engineering, University of Padova, Padova, Italy.
• February 18^th, 2013: “Computational Modeling of T-Cell Formation Reveals Proliferation-Linked Developmental Competence at Early Stages”. First Annual Winter q-bio Meeting – Quantitative Biology, Honolulu, Hawaii, U.S.A., February 18-21, 2013.
• September 29^th, 2011: “Dynamics Inside the Hematopoietic Hierarchy in Adult Mice”. 11^th Swedish Bioinformatics Workshop, Lund, Sweden.
• October 19^th, 2009: “Dynamics of Pancreatic Beta-Cells”. Department of Theoretical Physics, Lund University, Lund, Sweden.
• December 19^th, 2008: “A Dynamic Model for Beta-Cell Turnover”. Larry L. Hillblom Islet Research Center, 4^th Birthday & Annual Review/Audit. Shutters on the Beach Hotel, Santa Monica, California, U.S.A.
• September 8^th, 2008: “Attempted β-cell Regeneration from Replication Independent Sources in a Rat Model of Type 2 Diabetes”.
  4^th European Association for the Study of Diabetes Annual Meeting, Roma, Italy, September 7-11, 2008.
• October 17^th, 2007: “Models on Beta-Cell Turnover in Rats and Young Humans”. Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, Division of Endocrinology, Diabetes, and Hypertension, UCLA, Los Angeles, California, U.S.A.

• Tanaka K., Saisho Y., Manesso E., Tanaka M., Meguro S., Irie J., Sugiura H., Kawai T., Jinzaki M., Cobelli C., Itoh H. and on behalf of the KIND-LM study investigators. Effects of liraglutide monotherapy on beta cell function and pancreatic enzymes compared with metformin in Japanese overweight/obese patients with type 2 diabetes: A subpopulation analysis of the KIND-LM randomized trial. Clinical Drug Investigation (2015). external pageabstractcall_made
• Tessari P., Kiwanuka E., Barazzoni R., Toffolo G.M., Vettore M., Cortella I., Manesso E., Pasqualetto G., Puricelli L., Gabelli C. and Zanetti M. Decreased VLDL-Apo B 100 fractional synthesis rate despite hypertriglyceridemia in subjects with type 2 diabetes and nephropathy. J Clin Endocrinol Metab (2015). external pageabstractcall_made
• Liu Y., Manesso E. and Gunawan R. REDEMPTION: Reduced Dimension Ensemble Modeling and Parameter Estimation. Bioinformatics (2015). external pageabstractcall_made
• Manesso E., Teles J., Bryder D., and Peterson C. Dynamical Modeling of Haematopoiesis: an Integrated View over the System in Homeostasis and under Perturbation. J.R. Soc. Interface 2013 Mar 6; 10(80):20120817. external pageabstractcall_made
• Manesso E., Chickarmane V., Kueh H.Y., Rothenberg E.V., and Peterson C. Computational Modeling of T-cell Formation Kinetics: Output Regulated by Initial Proliferation-linked Deferral of Developmental Competence. J. R. Soc. Interface 2013 Jan 6; 10(78):20120774. external pageabstractcall_made
• Saisho Y., Butler A.E., Manesso E., Elashoff D., Rizza R.A., and Butler P.C. β-Cell Mass and Turnover in Humans: Effects of Obesity and Aging. Diabetes Care 2013 Jan; 36(1):111-7. external pageabstractcall_made
• Manesso E., Toffolo G.M., Butler A.E., Butler P.C., and Cobelli C. Shortened β-Cell Lifespan Leads to β-Cell Deficit in a Rodent Model of Type 2 Diabetes. Am. J. Physiol. Endocrinol. Metab. 2011 May; 300(5):E933-8. external pageabstractcall_made
• Manesso E., Toffolo G.M., Basu R., Rizza R.A., and Cobelli C. Modelling NonSteady State Metabolism from Arteriovenous Data. IEEE Trans. Biomed. Eng. 2011 May; 58(5):1253-9. external pageabstractcall_made
• Saisho Y., Manesso E., Butler A.E., Galasso R., Kavanagh K., Flynn M., Zhang L., Clark P., Gurlo T., Toffolo G.M., Cobelli C., Wagner J.D., Butler P.C. Ongoing β-Cell Turnover in Adult NonHuman Primates is not Adaptively Increased in Streptozotocin-Induced Diabetes. Diabetes 2011 Mar; 60(3):848-56. external pageabstractcall_made
• van der Heijden G.J., Wang Z.J., Chu Z., Toffolo G.M., Manesso E., Sauer P.J., and Sunehag A.L. Strength Exercise Improves Muscle Mass and Hepatic Insulin Sensitivity in Obese Youth. Med. Sci. Sports Exerc. 2010 Nov; 42(11):1973-80. external pageabstractcall_made
• Saisho Y., Butler A.E., Manesso E., Galasso R., Zhang L., Gurlo T., Toffolo G.M., Cobelli C., Kavanagh K., Wagner J.D., and Butler P.C. Relationship between Fractional Pancreatic β-Cell Area and Fasting Plasma Glucose Concentration in Monkeys. Diabetologia 2010 Jan; 53(1):111-4. external pageabstractcall_made
• van der Heijden G.J., Toffolo G.M., Manesso E., Sauer P.J., and Sunehag A.L. Aerobic Exercise Increases Peripheral and Hepatic Insulin Sensitivity in Sedentary Adolescents. J. Clin. Endocrinol. Metab. 2009 Nov; 94(11):4292-9. external pageabstractcall_made
• Manesso E., Toffolo G.M., Saisho Y., Butler A.E., Matveyenko A.V., Cobelli C., and Butler P.C. Dynamics of β-Cell Turnover; Evidence for β-Cell Turnover and Regeneration from Sources of β-Cells other than β-Cell Replication
  in the HIP Rat. Am. J. Physiol. Endocrinol. Metab. 2009 Aug; 297(2):E323-30. external pageabstractcall_made
• Saisho Y., Manesso E., Gurlo T., Huang C., Toffolo G.M., Cobelli C., and Butler P.C. Development of Factors to Convert Frequency to Rate for β-Cell Replication and Apoptosis Quantified by Time Lapse Video Microscopy and Immunohistochemistry. Am. J. Physiol. Endocrinol. Metab. 2009 Jan; 296(1):E89-96. external pageabstractcall_made

2013-present Postdoctoral Fellow, ETH Zürich

2010-2013 Senior Research Fellow, Lund University

2012 Visiting Postdoctoral Scholar, California Institute of Technology

2008 Staff Research Assistant, University of California Los Angeles

2006 Research Assistant, University of Padova