Dr. Lakshmi Narayanan Lakshmanan

Education

2014 PhD Chemical Engineering, NUS, Singapore

2008 M.Tech. Medical Biotechnology, IIT Madras, India

2006 B.Tech. Industrial Biotechnology, MSEC Sivakasi, India

Experience

November 2014 - January 2017 Postdoctoral Fellow, ETH Zurich

April - October 2014 Research Assistant, Yale-NUS Singapore

August 2012 - January 2014 Academic Visitor, ETH Zurich

Presentations

  • LN. Lakshmanan, Z. Yee, J. Gruber, B. Halliwell and R.Gunawan,  Deletion mutagenesis of mitochondrial DNA. In Cell Fate Diversity in Aging, Dubrovnik, Croatia, 25-28 September 2016. (poster)
  • LN. Lakshmanan and R. Gunawan, Thermodynamics Based Model Analysis of Deletion Mutagenesis in Mitochondrial DNA, In the 14th AIChE Annual Meeting, Atlanta, GA, November 16 – November 21, 2014. (talk)
  • LN. Lakshmanan, J. Gruber, and R. Gunawan, Mitochondrial DNA Deletion Mutagenesis in Aging. In International Conference of Systems Biology, Toronto, Canada, August 2012. (poster)
  • LN. Lakshmanan, J. Gruber, B. Halliwell and R. Gunawan, Role of Direct Repeats and DNA Misalignments in mtDNA Deletions: Cause or Coincidence? In Gordon Research Conference on Biology of Aging, Ventura, California, USA, February 2012. (poster)
  • LN. Lakshmanan, J. Gruber, B. Halliwell and R. Gunawan, Mitochondrial DNA Deletions in Aging – Role of DNA Sequence Motifs. In the 12th International Conference on Systems Biology, Mannheim, Germany, August 28 - September 1, 2011. (poster)
  • LN. Lakshmanan, S. K. Poovathingal, and R. Gunawan, Modeling of Age-associated Mitochondrial DNA Deletions in Mouse Cardiac Tissue. In the Conference on Stochastic Systems Biology, Monte Verità, Switzerland, July 2011. (poster)
  • LN. Lakshmanan, S. K. Poovathingal, and R. Gunawan, Mouse cardiac tissue modeling of age-associated deletions in mitochondrial genome. In The 8th Workshop in Computational System Biology, Zurich, Switzerland, June 2011.
    (poster)
  • LN. Lakshmanan, S. K. Poovathingal, J. Gruber, B. Halliwell and R. Gunawan, Elucidating Mechanisms of Age-dependent Accumulation of Mitochondrial DNA Deletions – An in silico Approach. In Gordon Research Conference on Biology of Aging, Les Diablerets, Switzerland, August 2010. (poster)

Publications

  • Fong, S., Teo, E., Ng, LF., Chen, CB., Lakshmanan, LN., Tsoi, SY., Moore, PK., Inoue, T., Halliwell, B. and Gruber, J. Energy crisis precedes global metabolic failure in a novel Caenorhabditis elegans Alzheimer Disease model. Scientific Reports 6 (2016). external pageabstract
  • Lakshmanan, LN., Gruber, J., Halliwell, B. and Gunawan, R. Are mutagenic non D-loop direct repeat motifs in mitochondrial DNA under a negative selection pressure?. Nucleic Acids Research (2015). external pageabstract
  • Poovathingal, S. K., Gruber, J., Lakshmanan, LN., Halliwell, B. and Gunawan, R. Is mitochondrial DNA turnover slower than commonly assumed? Biogerontology 13, 557-564 (2012) . external pageabstract
  • Lakshmanan, LN., Gruber, J., Halliwell, B. and Gunawan, R. Role of direct repeat and stem-loop motifs in mtDNA deletions: cause or coincidence? PloS one 7, e35271 (2012). external pageabstract
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